کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2403212 | 1102889 | 2012 | 8 صفحه PDF | دانلود رایگان |
This study compared the safety and immunogenicity of DTaP5-IPV-Hib vaccine (followed by monovalent hepatitis B vaccine [HBV]) and DTaP3-HBV-IPV/Hib vaccines, both coadministered with PCV7, as a fourth-dose booster in toddlers 11–18 months who had a hexavalent vaccine primary series. The fever rate within 4 days of DTaP5-IPV-Hib was noninferior to DTaP3-HBV-IPV/Hib. DTaP5-IPV-Hib induced a marked immune response and had a similar safety and immunogenicity profile compared with DTaP3-HBV-IPV/Hib. Fully liquid DTaP5-IPV-Hib can be used as a booster after a hexavalent vaccine primary series; where required, a fourth dose of monovalent HBV can be administered after DTaP5-IPV-Hib (NCT ID: NCT00355654).
► DTaP5-IPV-Hib and DTaP3-HBV-IPV/Hib were compared as 4th dose boosters in toddlers.
► Both DTaP5-IPV-Hib and DTaP3-HBV-IPV/Hib were coadministered with PCV7.
► Fever rates of DTaP5-IPV-Hib were noninferior to DTaP3-HBV-IPV/Hib.
► DTaP5-IPV-Hib and DTaP3-HBV-IPV/Hib had similar safety and immunogenicity profiles.
► DTaP5-IPV-Hib can be used as a booster after a hexavalent vaccine primary series.
Journal: Vaccine - Volume 30, Issue 35, 27 July 2012, Pages 5270–5277