کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2403414 | 1102904 | 2011 | 6 صفحه PDF | دانلود رایگان |
Taiwan started to immunize children in 30 indigenous townships against hepatitis A since June 1995. The program was further expanded to 19 non-indigenous townships with higher incidence or increased risk of epidemic in 1997–2002, covering 2% of total population. Annual incidence of hepatitis A decreased from 2.96 in 1995 (baseline period) to 0.90/100,000 in 2003–2008 (vaccination period). The incidence in vaccinated townships and unvaccinated townships declined 98.3% (49.66–0.86/100,000) and 52.6% (1.90–0.90/100,000). In 2003–2008, incidence doubled in people aged >=30 years, mostly in unvaccinated townships (0.42–0.92). During 2003–2008, travel to endemic countries was the most commonly reported risk factor (13.5%). First dose vaccine coverage was 78.8% in 1994–2005 birth cohort. Taiwan's experience demonstrates the great, long-term efficacy of hepatitis A vaccine in disease control in vaccinated townships, and out-of-cohort effect in unvaccinated townships. Further reduction can be achieved by improving vaccination coverage of adults at risk.
Journal: Vaccine - Volume 29, Issue 16, 5 April 2011, Pages 2956–2961