کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2403852 1102936 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Longitudinal 2 years field study of conventional vaccination against highly pathogenic avian influenza H5N1 in layer hens
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Longitudinal 2 years field study of conventional vaccination against highly pathogenic avian influenza H5N1 in layer hens
چکیده انگلیسی

A licensed, inactivated vaccine based on a low pathogenic avian influenza virus strain (H5N2) was evaluated in layer hens kept under field conditions during a 2-year period. Vaccine efficacy was investigated by specific antibodies and by challenge-contact experiments using highly pathogenic avian influenza viruses (HPAIV) H5N1. Basic immunization with two applications induced clinical protection. Virus excretion by vaccinated hens was significantly reduced compared to non-vaccinated controls; transmission to non-vaccinated and vaccinated contact birds was not fully interrupted. Vaccination efficacy is influenced by several factors including antigenic relatedness between vaccine and field strains, but also by species, age and type of commercial uses of the host. Limitations and risks of HPAIV vaccination as silent spread of HPAIV and emergence of escape mutants must be considered a priori and appropriate corrective measures have to be installed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 42, 4 October 2010, Pages 6832–6840
نویسندگان
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