کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2403956 | 1102943 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigation of memory B cell responses to hepatitis B surface antigen in health care workers considered as non-responders to vaccination
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Investigation of memory B cell responses to hepatitis B surface antigen in health care workers considered as non-responders to vaccination Investigation of memory B cell responses to hepatitis B surface antigen in health care workers considered as non-responders to vaccination](/preview/png/2403956.png)
چکیده انگلیسی
Up to 20% of health care workers are considered as non-responders to hepatitis B vaccination (anti-HBs < 10 mUI/ml in serum). We have explored memory B cells differentiated in vitro into anti-HBs antibody-secreting cells (anti-HBs-SCs) by ELISPOT assay. Anti-HBs-SCs were detected in vaccinated responders (n = 11) and non-responders (n = 10) but IgG anti-HBs-SCs were significantly lower in the non-responder group (p < 0.001). Low amounts of HBs antibodies were also quantified by ELISA in non-responders’ sera. These results indicate that a suboptimal B cell response exists in non-responders to HBV vaccination. This B cell response may mediate a protection against clinically significant breakthrough hepatitis B infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 39, 7 September 2010, Pages 6411–6416
Journal: Vaccine - Volume 28, Issue 39, 7 September 2010, Pages 6411–6416
نویسندگان
J.C. Valats, E. Tuaillon, N. Funakoshi, D. Hoa, M.C. Brabet, K. Bolloré, J. Ducos, J.P. Vendrell, P. Blanc,