کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2404006 1102945 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long term immunity following a booster dose of the inactivated Japanese Encephalitis vaccine IXIARO®, IC51
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Long term immunity following a booster dose of the inactivated Japanese Encephalitis vaccine IXIARO®, IC51
چکیده انگلیسی

IntroductionIXIARO (IC51), a recently approved inactivated Japanese Encephalitis vaccine, is immunogenic and safe in a 0/28 days primary immunization schedule. Neutralizing antibody titers decline with time and booster doses are likely needed to enhance persistence of immunity.ObjectivesTo assess the effect of a booster dose on neutralizing JE antibody titers for up to 12 months after boostering.MethodsIn this phase III trial, 198 subjects, who had received primary immunization in a preceding randomized trial, were boosted with IXIARO 15 months after the primary immunization. Neutralizing antibody titers were assessed by plaque-reduction neutralisation test, PRNT.ResultsPrior to the booster dose, 69.2% (137/198) of subjects had PRNT50 titers ≥1:10. One month after the booster, the rate of subjects with PRNT50 ≥ 1:10 (recognized as a protective titer) was 100%. This rate remained high at 98.5% at 6 and 12 months; GMTs were 22.5 before the booster and 900, 487 and 361 at 1, 6 and 12 months after the booster, respectively.ConclusionA booster dose of IXIARO at 15 months after primary immunization was highly immunogenic with GMTs >5-fold higher than those seen immediately after primary immunization, and remained at high levels for at least 12 months after the booster. NCT00595309.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 29, Issue 14, 21 March 2011, Pages 2607–2612
نویسندگان
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