کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2404023 1102947 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeted microbeads for attraction and induction of specific innate immune response in the tumor microenvironment
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Targeted microbeads for attraction and induction of specific innate immune response in the tumor microenvironment
چکیده انگلیسی

Antitumor activity of molecules and cells of the innate immune system has been reported. Here we propose a method for targeting preferred innate immune cells and magnifying their tumoricidal effect at the tumor microenvironment, by modular multiple-component complexes (termed TILTAN). As a model, micro-scale complexes were assembled carrying monoclonal anti-HER2 antibodies, lipopolysaccharide and/or mannose. The complexes showed high binding capacity to HER2-positive cancer cells in vitro, high induction of interleukin-1 RNA transcription by the activated monocytes and ability to mediate monocytes’ attachment to HER2-positive cells. TILTAN treatment was found safe in in vivo testing and induced change in interleukin-1 RNA transcription in tumors xenografts. We thus present a new vision of targeting a desired innate immune response to the tumor microenvironment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 45, 21 October 2010, Pages 7279–7287
نویسندگان
, , , , ,