کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2404353 1102971 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes
چکیده انگلیسی

The amino terminal region of group A streptococcal M proteins evokes type-specific immunity while the conserved C-repeat epitopes evoke cross-protective immunity against multiple serotypes. The present studies were undertaken to compare the protective efficacy of vaccines containing either type-specific (hexavalent vaccine) or conserved C-repeat (J14 vaccine) M protein epitopes and to determine if combination vaccines resulted in enhanced levels of protection. Our results indicated that the protective efficacy of the type-specific vaccine was significantly greater than that of J14 and that the addition of J14 to vaccine formulations did not enhance the level of protection achieved with type-specific formulations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 31, 12 July 2010, Pages 5017–5022
نویسندگان
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