کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2404414 1102975 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glycoconjugate vaccines and immune interference: A review
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Glycoconjugate vaccines and immune interference: A review
چکیده انگلیسی

Bacterial polysaccharide–protein conjugate vaccines (Haemophilus influenzae type b [Hib], pneumococcal and meningococcal conjugates) have revolutionized pediatric vaccination strategies. The widely used carrier proteins are tetanus toxoid (TT), diphtheria toxoid (DT) and diphtheria toxoid variant CRM197 protein, DT conjugates being in general less immunogenic. Multivalent conjugates using TT were found to be at risk for reduced polysaccharide responses, whilst multivalent CRM197 conjugates are at lower risk for this, but may be at higher risk of inducing bystander interference, particularly affecting Hib and hepatitis B immune responses. Novel carriers avoiding these issues could enable the further development of pediatric schedules and combinations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 34, 2 August 2010, Pages 5513–5523
نویسندگان
, , ,