کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2404465 1102979 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibody against Haemophilus influenzae protein D in patients with chronic conditions causing secondary immunodeficiency
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Antibody against Haemophilus influenzae protein D in patients with chronic conditions causing secondary immunodeficiency
چکیده انگلیسی

Prevalence of non-typeable Haemophilus influenzae (NTHi) in the etiology of invasive infections in immunocompromised individuals is increasing. Serum IgG antibody levels to H. influenzae protein D (PD) were significantly lower in adults suffering from chronic conditions causing secondary immunodeficiency (COPD, cancer, chronic renal failure, and diabetes) compared to age-matched healthy controls. A lack of naturally acquired antibody against this highly conserved antigen may contribute to an increased susceptibility to invasive NTHi disease. As COPD patients frequently infected with NTHi during disease exacerbations were unable to develop antibody response to PD, such defect could potentially contribute to the pathogenesis. Considering that pediatric PD-containing vaccines show protective effect against NTHi-caused otitis media, our data suggest the possibility of improving the defense against NTHi in COPD patients using immunization against PD. Although more research on the role of anti-PD antibody in protection against invasive NTHi disease is warranted, development of adult formulations of PD-based vaccines may be advantageous for prevention of severe infections in immunocompromised individuals.


► Normal adults have naturally acquired antibody against protein D of Haemophilus influenzae.
► The antibody levels decline with advanced age.
► Individuals with secondary immunodeficiency lack this antibody.
► This may contribute to their increased susceptibility to invasive NTHi disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 30, Issue 7, 8 February 2012, Pages 1235–1238
نویسندگان
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