کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2404576 1102985 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mitochondria-centric activation induced cell death of cytolytic T lymphocytes and its implications for cancer immunotherapy
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Mitochondria-centric activation induced cell death of cytolytic T lymphocytes and its implications for cancer immunotherapy
چکیده انگلیسی

Premature death of the adoptively transferred cytolytic T lymphocytes (CTL) by means of activation induced cell death (AICD) represents one of the major constraints in devising an effective anti-cancer immune intervention strategy. Understanding the mechanism of AICD is, therefore, critical for developing methods to interfere with this death process. Although the existing paradigm on AICD centers around the initiation of the cascade of events originating from the engagement of death receptors leading to the activation of effector caspases and eventually resulting in cell death, recent findings have questioned the universal role of caspases as the cell death executioners. We here review our current understanding of the contribution of caspase-dependent and caspase-independent death executioners in AICD of T cells. We will also discuss the involvement of mitochondria-centric death pathway in AICD of human tumor associated antigen-specific primary CTL and its implications in cancer immunotherapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 29, 23 June 2010, Pages 4566–4572
نویسندگان
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