کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2404785 | 1102998 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity](/preview/png/2404785.png)
چکیده انگلیسی
Rice-expressed cholera toxin B (CTB) subunit is a cold-chain-free oral vaccine that effectively induces enterotoxin-neutralising immunity. We created another rice-based vaccine, MucoRice, expressing nontoxic double-mutant cholera toxin (dmCT) with CTA and CTB subunits. Western-blot analysis suggested that MucoRice-dmCT had the shape of a multicomponent vaccine. Oral administration of MucoRice-dmCT induced CTB- but not CTA-specific serum IgG and mucosal IgA antibodies, generating protective immunity against cholera toxin without inducing rice-protein-specific antibody responses. The potency of MucoRice-dmCT was equal to that of MucoRice-CTB vaccine. MucoRice has the potential to be used as a safe multicomponent vaccine expression system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Issue 43, 9 October 2009, Pages 5982–5988
Journal: Vaccine - Volume 27, Issue 43, 9 October 2009, Pages 5982–5988
نویسندگان
Yoshikazu Yuki, Daisuke Tokuhara, Tomonori Nochi, Hiroshi Yasuda, Mio Mejima, Shiho Kurokawa, Yuko Takahashi, Nobuhiro Kataoka, Ushio Nakanishi, Yukari Hagiwara, Kohtaro Fujihashi, Fumio Takaiwa, Hiroshi Kiyono,