کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2404825 | 1103002 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nicotine hapten structure, antibody selectivity and effect relationships: Results from a nicotine vaccine screening procedure
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The aim of the present study was to synthesise and screen a set of novel nicotine hapten immunogens used for the treatment of nicotine dependence. In the screening process we studied the amount of antibodies generated and their selectivity, using ELISA techniques, and their effects on nicotine-induced dopamine release in the NACshell of the rat, assessed by in vivo voltammetry. We conclude that even small changes such as the linker attachment on the nicotine molecule as well as the structure of the linker may greatly influence the selectivity of the antibodies and the central neurobiological effects of nicotine that are considered critical for its dependence producing properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 10, 2 March 2010, Pages 2161–2168
Journal: Vaccine - Volume 28, Issue 10, 2 March 2010, Pages 2161–2168
نویسندگان
Sabina H.L. de Villiers, Nina Lindblom, Genadiy Kalayanov, Sandra Gordon, Ivan Baraznenok, Anna Malmerfelt, Monica M. Marcus, Anette M. Johansson, Torgny H. Svensson,