کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2404991 1103009 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimized subunit vaccine protects against experimental leishmaniasis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Optimized subunit vaccine protects against experimental leishmaniasis
چکیده انگلیسی

Development of a protective subunit vaccine against Leishmania spp. depends on antigens and adjuvants that induce appropriate immune responses. We evaluated a second generation polyprotein antigen (Leish-110f) in different adjuvant formulations for immunogenicity and protective efficacy against Leishmania spp. challenges. Vaccine-induced protection was associated with antibody and T cell responses to Leish-110f. CD4 T cells were the source of IFN-γ, TNF, and IL-2 double- and triple-positive populations. This study establishes the immunogenicity and protective efficacy of the improved Leish-110f subunit vaccine antigen adjuvanted with natural (MPL-SE) or synthetic (EM005) Toll-like receptor 4 agonists.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Issue 50, 23 November 2009, Pages 7036–7045
نویسندگان
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