کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2405060 | 1103011 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vaccination with multimeric L2 fusion protein and L1 VLP or capsomeres to broaden protection against HPV infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Vaccination with multimeric L2 fusion protein and L1 VLP or capsomeres to broaden protection against HPV infection Vaccination with multimeric L2 fusion protein and L1 VLP or capsomeres to broaden protection against HPV infection](/preview/png/2405060.png)
چکیده انگلیسی
Immunization with L1 as pentavalent capsomeres or virus-like particles (VLPs) generates high and long-lived titers of neutralizing antibodies and protection primarily against the human papillomavirus (HPV) type from which the vaccine was derived. Conversely, vaccination with L2 minor capsid protein derived from multiple HPV types induces lower titer, but more broadly neutralizing and protective antibody responses. We combined the advantages of each protective antigen by immunization with titrated doses of multi-type L2 with either L1 capsomeres or VLP. We observed no significant interference between the L1 and L2 antibody response upon co-administration of L1 vaccines with multi-type L2 vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 28, 17 June 2010, Pages 4478–4486
Journal: Vaccine - Volume 28, Issue 28, 17 June 2010, Pages 4478–4486
نویسندگان
Subhashini Jagu, Kihyuck Kwak, Robert L. Garcea, Richard B.S. Roden,