کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2405181 | 1103018 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunoprotective activities of a Streptococcus suis pilus subunit in murine models of infection
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Immunoprotective activities of a Streptococcus suis pilus subunit in murine models of infection Immunoprotective activities of a Streptococcus suis pilus subunit in murine models of infection](/preview/png/2405181.png)
چکیده انگلیسی
Pili of gram-positive bacteria are key virulence factors and their subunits are considered excellent vaccine candidates. Streptococcus suis is an emerging zoonotic agent that can cause epidemics of life-threatening infections in humans, but the functional role or immunoprotective potential of its pilus components have not been studied yet. Using a selective proteomics approach, we have identified a surface protein of serotype 2 S. suis showing features of an ancillary pilus subunit, as evidenced by bioinformatics analysis, immunoblot and immunoelectron microscopy. Immunization with recombinant fragments of this protein, designated herein as PAPI-2b, markedly protected mice from systemic S. suis infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 20, 30 April 2010, Pages 3609–3616
Journal: Vaccine - Volume 28, Issue 20, 30 April 2010, Pages 3609–3616
نویسندگان
Manuela Garibaldi, Manuel J. Rodríguez-Ortega, Francesca Mandanici, Angela Cardaci, Angelina Midiri, Salvatore Papasergi, Orazio Gambadoro, Vittorio Cavallari, Giuseppe Teti, Concetta Beninati,