کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2405257 1103027 2009 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ISCOMs and ISCOMATRIX™
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
ISCOMs and ISCOMATRIX™
چکیده انگلیسی

Immunostimulatory complexes (ISCOMs) are particulate antigen delivery systems composed of antigen, cholesterol, phospholipid and saponin, while ISCOMATRIX™ is a particulate adjuvant comprising cholesterol, phospholipid and saponin but without antigen. The combination of an antigen with ISCOMATRIX™ is called an ISCOMATRIX™ vaccine. ISCOMs and ISCOMATRIX™ combine the advantages of a particulate carrier system with the presence of an in-built adjuvant (Quil A) and consequently have been found to be more immunogenic, while removing its haemolytic activity of the saponin, producing less toxicity. ISCOMs and ISCOMATRIX™ vaccines have now been shown to induce strong antigen-specific cellular or humoral immune responses to a broad range of antigens of viral, bacterial, parasite origin or tumor in a number of animal species including non-human primates and humans. These vaccines produced by well controlled and reproducible processes have also been evaluated in human clinical trials. In this review, we summarize the recent progress of ISCOMs and ISCOMATRIX™, including preparation technology as well as their application in humans and veterinary vaccine designs with particular emphasis on the current understanding of the properties and features of ISCOMs and ISCOMATRIX™ vaccines to induce immune responses. The mechanisms of adjuvanticity are also discussed in the light of recent findings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Issue 33, 16 July 2009, Pages 4388–4401
نویسندگان
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