کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2405381 | 1103032 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Safety and efficacy of novel dermal and epidermal microneedle delivery systems for rabies vaccination in healthy adults
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
In the present pilot study, intradermal ID delivery systems with a BD microneedle from 1 to 3 mm in length, and epidermal delivery (BD skin abrader) through abraded skin surface relative to standard intramuscular injection were evaluated. Circulating neutralizing antibodies were measured against the rabies virus after the Vero cells rabies vaccine was administered at D0, D7, D21 and D49. This clinical evaluation in 66 healthy volunteers shows that ID delivery using BD microneedle technology of 1/4 the IM antigen dose is safe, efficient and reliable, resulting in a protective seroconversion rate. In contrast, the epidermal delivery route did not produce an immune response against the rabies vaccine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 36, 16 August 2010, Pages 5850–5856
Journal: Vaccine - Volume 28, Issue 36, 16 August 2010, Pages 5850–5856
نویسندگان
Philippe E. Laurent, Hervé Bourhy, Marc Fantino, Paul Alchas, John A. Mikszta,