کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2405539 1551780 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
On the relationship between meningococcal transmission dynamics and disease: Remarks on humoral immunity
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
On the relationship between meningococcal transmission dynamics and disease: Remarks on humoral immunity
چکیده انگلیسی

We consider a model for the transmission dynamics of Neisseria meningitidis which incorporates the humoral immunity hypothesis in an explicit way. The “humoral immunity” hypothesis states that individuals will experience significantly different risks of invasive disease depending on whether they are experiencing their first infection episode, or a subsequent one. The model is fitted to the Stonehouse–Danbury carriage data and to UK disease data. For serogroup C (B) the risk of disease during the first infection episode results to be 100 (400) times higher compared to subsequent ones. Moreover the best-fit corresponds to the situation where N. lactamica essentially always confers cross-protection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Issues 25–26, 26 May 2009, Pages 3429–3434
نویسندگان
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