کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2406099 1103063 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Girls may have lower levels of maternal measles antibodies and higher risk of subclinical measles infection before the age of measles vaccination
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Girls may have lower levels of maternal measles antibodies and higher risk of subclinical measles infection before the age of measles vaccination
چکیده انگلیسی

BackgroundPrevious studies have suggested that girls may have lower maternal measles antibody levels than boys. Girls might therefore be more likely to contract measles infection before the normal age of measles vaccination at 9 months of age.MethodsIn connection with a clinical trial of different measles vaccination strategies, we collected pre-measles vaccination blood samples at 4.5 months of age from two subgroups of children. Samples from these children were used to assess possible differences in maternal antibody levels for boys and girls. At 9 months of age another subgroup of children was sampled before the normal measles vaccination; these samples were used to assess the frequency of subclinical measles infection among boys and girls.ResultsWe determined measles-specific antibody levels for 812 children at 4.5 months of age and for 896 children at 9 months of age. At 4.5 months of age girls were less likely to have protective maternal antibody levels, the male–female ratio for protective antibody level being 1.23 (1.00–1.51). Among children sampled at 9 months of age, girls were more likely to have protective levels, the female–male ratio for having protective antibody levels being 1.65 (0.98–2.78) (p = 0.054) and the geometric mean titre was significantly higher for girls (p = 0.007). Children who lived in houses with known measles cases were more likely to have protective levels at 9 months of age even though they had not reported measles infection. Since we had excluded children with known measles infection, girls may have been more likely to have had subclinical measles infection. Combining clinical and possible subclinical measles infection, girls tended to be more likely than boys to contract measles infection before 9 months of age, the RR being 1.36 (0.97–1.90).ConclusionsGirls lost maternal measles antibodies more rapidly than boys and well before 9 months of age. They may be more likely to contract subclinical measles infection before the current age of measles vaccination.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Issue 38, 20 August 2009, Pages 5220–5225
نویسندگان
, , , , , , , , , ,