کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2406381 1103078 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Controlled, single-step, stratum corneum disruption as a pretreatment for immunization via a patch
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Controlled, single-step, stratum corneum disruption as a pretreatment for immunization via a patch
چکیده انگلیسی

SummaryA Skin Prep System (SPS) has been developed to provide a well-tolerated and controlled method of stratum corneum disruption using mild abrasion as part of transcutaneous immunization (TCI). In this study, four groups (n = 10) of volunteers were pretreated with the SPS using three different lengths of mild abrasive strips (13 mm, 25 mm and 38 mm), or a handheld applicator. They then received a vaccine patch containing 50 μg of the heat-labile enterotoxin from Escherichia coli (LT) at day 0 and day 21. Subsequent anti-LT IgG antibody responses were dependent on abrasive strip length, with highest immune responses seen after use of the longest strip. The development of a simple, single-use, disposable device that is well-tolerated and allows disruption to be modulated represents an important step forward in physical penetration enhancement for the skin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 26, Issue 22, 23 May 2008, Pages 2782–2787
نویسندگان
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