کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2406503 1103083 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Delivery of vaccine peptides by rapid conjugation to baculovirus particles
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Delivery of vaccine peptides by rapid conjugation to baculovirus particles
چکیده انگلیسی

SummaryBaculoviruses deliver strong activation signals to dendritic cells and can promote potent immune responses. These properties can be harnessed to use baculovirus as an adjuvant and carrier particle for immunogenic peptides. In this study we use a chemical linker to couple peptides to the baculovirus Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV). Intranasal delivery of baculovirus coupled with immunogenic peptides to mice elicited antigen-specific IgG1 and IgG2a antibody. Furthermore, antigen-specific IgA was detected in the lung, and an IFN-γ response was observed upon re-stimulation with antigen. We show that chemical coupling enables the rapid modification of AcMNPV, allowing multiple epitopes to be delivered simultaneously on a self-adjuvanting carrier particle.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 26, Issue 20, 12 May 2008, Pages 2451–2456
نویسندگان
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