کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2406683 | 1103091 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intranasal cowpox virus infection of the mouse as a model for preclinical evaluation of smallpox vaccines
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Intranasal cowpox virus infection of the mouse as a model for preclinical evaluation of smallpox vaccines Intranasal cowpox virus infection of the mouse as a model for preclinical evaluation of smallpox vaccines](/preview/png/2406683.png)
چکیده انگلیسی
The intranasal infection of mice with cowpox virus (CPXV) has been evaluated as a model for smallpox infection in man. Administration of a lethal dose of CPXV allowed time for development of T-cell responses but antibodies could not be detected before death occurred. In contrast, infection with a sublethal dose was associated with an early T-cell response followed by neutralising antibodies which correlated with virus clearance. Comparison of two first generation smallpox vaccines revealed no significant differences in terms of immunogenicity, protection and post-challenge virus clearance. These studies show that the CPXV/mouse model is valuable for the initial assessment of smallpox vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 25, 15 June 2007, Pages 4809–4817
Journal: Vaccine - Volume 25, Issue 25, 15 June 2007, Pages 4809–4817
نویسندگان
Audrey Ferrier-Rembert, Robert Drillien, Jean-Nicolas Tournier, Daniel Garin, Jean-Marc Crance,