کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2406788 | 1103096 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Single CX3CL1-Ig DNA administration enhances T cell priming in vivo Single CX3CL1-Ig DNA administration enhances T cell priming in vivo](/preview/png/2406788.png)
Upon antigenic stimulation, establishment of adaptive immune responses that determines vaccine efficacy is dependent on efficient T cell priming. Here, single CX3CL1-Ig DNA administration, a unique ligand of CX3CR1, together with viral or tumor antigens induced a strong in vivo antigen-specific T cell proliferation and effector function that was enough efficient to protect against a tumor challenge. We also showed that early expression of CX3CL1-Ig and antigens in muscle and lymphoid organs induces an increased in vivo migration of myeloid CD14+CD11c+ DC but not lymphoid CD8α+CD11c+ DC at these sites. Thus, by effectively directing DC toward lymphoid organs to encounter T cells, CX3CL1-Ig become a new candidate that augments T cell priming and increases efficiency of vaccination.
Journal: Vaccine - Volume 25, Issue 23, 6 June 2007, Pages 4554–4563