کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2406829 1103097 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development and characterization of candidate rotavirus vaccine strains derived from children with diarrhoea in Vietnam
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Development and characterization of candidate rotavirus vaccine strains derived from children with diarrhoea in Vietnam
چکیده انگلیسی

In Vietnam, rotavirus infection accounts for more than one-half of all hospitalizations for diarrhoea among children less than 5 years of age. While new vaccines to prevent rotavirus diarrhoea have been developed and introduced into some countries by multinational manufacturers, the ability for developing countries such as Vietnam to introduce several new and important vaccines into the routine infant immunization schedule may be challenging. In order to be partially self-sufficient in vaccine production, Vietnam has pursued the development of several rotavirus strains as candidate vaccines using isolates obtained from Vietnamese children with diarrhoea. This paper describes the origin, isolation and characterization of 3 human rotavirus strains being considered for further vaccine development in Vietnam. The goal is to prepare a monovalent G1P [8] rotavirus vaccine using one of these strains obtained in Vietnam and naturally attenuated by multiple passages in cell culture. While this is an ambitious project that will require several years’ work, we are using the lessons learned to improve the overall quality of vaccine production including the use of Vero cell techniques for the manufacture of other vaccines in Vietnam.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Supplement 5, 20 November 2009, Pages F130–F138
نویسندگان
, , , , , , , , , , , , , , , ,