Japanese encephalitis protein vaccine candidates expressing neutralizing epitope and M.T hsp70 induce virus-specific memory B cells and long-lasting antibodies in swine

The group immunized with the epitope fused to M.T hsp70 made the strongest proliferation of lymphocytes. Through the assay of the amount of interferon (IFN)-γ and interleukin (IL)-4 in the serum, swine immunized with the fusion protein increased IFN-γ in the serum which showed that M.T hsp70 potentiated Th1 immune response.