کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2406964 1103104 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Booster vaccination of toddlers with reduced antigen content diphtheria–tetanus–acellular pertussis vaccine
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Booster vaccination of toddlers with reduced antigen content diphtheria–tetanus–acellular pertussis vaccine
چکیده انگلیسی

Immunogenicity and reactogenicity of DTPa and reduced antigen dTpa booster vaccines were compared to a hepatitis A control vaccine in DTPa-primed toddlers aged 18–20 months. Post-booster, all DTPa and dTpa recipients were seroprotected against diphtheria and tetanus, and ≥93.3% had a booster response to pertussis. There were similar reactogenicity rates in the DTPa and dTpa vaccine recipients. Few Grade 3 symptoms were reported. Just over one in four children in the control group had diphtheria antibody at or potentially below the correlate of protection benchmark (0.016 IU/ml). Larger studies should evaluate potential benefits of reduced antigen vaccines and seroprotection in children who do not receive a booster dose of DTPa at this age, including protection against diphtheria until subsequent booster doses are given.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Issue 18, 21 April 2009, Pages 2410–2413
نویسندگان
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