کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2407005 1103106 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The safety and immunogenicity of an in ovo vaccine against Newcastle disease virus differ between two lines of chicken
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The safety and immunogenicity of an in ovo vaccine against Newcastle disease virus differ between two lines of chicken
چکیده انگلیسی

Newcastle disease virus is a major threat to poultry and in ovo vaccines are needed. A live in ovo vaccine for Newcastle disease virus, which was licensed but not marketed, was unsafe. It killed 32% of line 0 chicks and 10% of vaccine Lohmann (VALO) chicks using the maximum recommended dose that infected about 40% of the embryos. VALO's made more antibody than line 0's whether infected in ovo or by contact. The vaccine interrupted the massive development of the air capillaries between injection and hatch 3 days later. Cytokines, delivered as DNA in plasmids, did not function as adjuvants. IFN-γ prevented infection. IL-4 or IL-18 had little or no effect. Line 0 chicks that had been infected by contact were protected and so the unsafe in ovo vaccination of a minority could protect the majority.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 19, 10 May 2007, Pages 3792–3799
نویسندگان
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