کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2407535 1103129 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
HPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine
چکیده انگلیسی

The efficacy of the quadrivalent Human Papillomavirus (HPV) vaccine is thought to be mediated by humoral immunity. We evaluated the correlation between quadrivalent HPV vaccine-induced serum anti-HPV responses and efficacy. 17,622 women were vaccinated at day 1, and months 2 and 6. At day 1 and at 6–12 months intervals for up to 48 months, subjects underwent Papanicolaou and genital HPV testing. No immune correlate of protection could be found due to low number of cases. Although 40% of vaccine subjects were anti-HPV 18 seronegative at end-of-study, efficacy against HPV 18-related disease remained high (98.4%; 95% CI: 90.5–100.0) despite high attack rates in the placebo group. These results suggest vaccine-induced protection via immune memory, or lower than detectable HPV 18 antibody titers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 26, Issue 52, 9 December 2008, Pages 6844–6851
نویسندگان
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