کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2407691 1551781 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimal allocation of pandemic influenza vaccine depends on age, risk and timing
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Optimal allocation of pandemic influenza vaccine depends on age, risk and timing
چکیده انگلیسی

The limited production capacity for vaccines raises the question what the best strategy is for allocating the vaccine to mitigate an influenza pandemic. We developed an age-structured model for spread of an influenza pandemic and validated it against observations from the Asian flu pandemic. Two strategies were evaluated: vaccination can be implemented at the start of the influenza pandemic, or vaccination will be implemented near the peak of it. Our results suggest prioritizing individuals with a high-risk of complications if a vaccine becomes available during a pandemic. If available at the start, vaccinating school children might be considered since this results in slightly lower expected number of deaths.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 26, Issues 29–30, 4 July 2008, Pages 3742–3749
نویسندگان
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