کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2408037 1103153 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immune response to two different dosing schedules of the anthrax vaccine precipitated (AVP) vaccine
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Immune response to two different dosing schedules of the anthrax vaccine precipitated (AVP) vaccine
چکیده انگلیسی

A pilot study compared the immune response of regular (0, 3, 6, 32 weeks) and extended (0, 10, 13, 32 weeks) schedules of the UK anthrax vaccine (anthrax vaccine precipitated, AVP). Concentrations of antibodies to protective antigen (PA) were higher (p < 0.05) among recipients of the extended (n = 7) versus regular schedule (n = 6) at week 32, and 2 weeks after the second and third vaccinations. Toxin neutralisation assay levels and anti-lethal factor antibodies followed patterns similar to anti-PA antibodies. Extending the interval between the first two AVP vaccinations may produce a stronger immune response, but persistence of this effect needs further study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 32, 10 August 2007, Pages 6089–6097
نویسندگان
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