کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2408187 1551784 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro interactions between macrophages and aluminum-containing adjuvants
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
In vitro interactions between macrophages and aluminum-containing adjuvants
چکیده انگلیسی

Intramuscular administration of aluminum-adjuvanted vaccines induces an infiltration of aluminum-containing macrophages between muscle fibers. In vitro stimulation of human monocyte-derived macrophages with aluminum hydroxide (AlOOH) induces similar intracellular crystalline inclusions as well as phenotypical and functional modifications. We compared in this study the ability of other adjuvants to exert similar changes in macrophages in vitro. All mineral salts, i.e. aluminic (AlOOH, AlPO4) and non-aluminic mineral adjuvants (CaPO4, FePO4) but not emulsion were able to increase macrophages capacity to potentiate autologous memory T lymphocyte proliferation, while only aluminic adjuvants induced CD83 expression and increased CD86 on macrophages. All together, this suggests that aluminic and non-aluminic adjuvants exerted their immunoactivities by distinct mechanisms on macrophages.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issues 37–38, 17 September 2007, Pages 6784–6792
نویسندگان
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