کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2408248 | 1103164 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The effect of pre-existing immunity on the capacity of influenza virosomes to induce cytotoxic T lymphocyte activity The effect of pre-existing immunity on the capacity of influenza virosomes to induce cytotoxic T lymphocyte activity](/preview/png/2408248.png)
SummaryProtein antigens encapsulated in virosomes generated from influenza virus can induce antigen-specific cytotoxic T lymphocyte (CTL) responses. In the present study we determined, in a murine model system, whether pre-existing immunity against influenza virus hampers the induction of a CTL response. CTL induction was only slightly reduced by pre-injection of influenza virus-specific antibodies or pre-exposure to influenza virus. Both pretreatments resulted in the same level of reduction, suggesting that virus-specific antibodies rather than T cell responses account for the reduction. Furthermore, a booster immunization enhanced CTL activation, indicating that virosome-specific immunity induced by a prime immunization does not hamper the booster effect. In conclusion, CTL induction against virosome-encapsulated protein antigens is not significantly inhibited by pre-existing humoral or cellular immunity against influenza virus.
Journal: Vaccine - Volume 26, Issue 19, 2 May 2008, Pages 2314–2321