کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2408315 1103167 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Site-specific UBITh® amyloid-β vaccine for immunotherapy of Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Site-specific UBITh® amyloid-β vaccine for immunotherapy of Alzheimer's disease
چکیده انگلیسی

The UBITh® AD immunotherapeutic vaccine for Alzheimer's disease uses an amyloid-β (Aβ) immunogen having two designer peptides that have been engineered to elicit anti-N terminal Aβ1–14 antibodies while minimizing potential for the generation of adverse anti-Aβ immune responses. The vaccine has been further designed for minimization of inflammatory reactivities through the use of a proprietary vaccine delivery system that biases Th2 type regulatory T cell responses in preference to Th1 pro-inflammatory T cell responses. In vitro studies and in vivo studies in small animals, baboons and macaques show that anti-Aβ antibodies are generated with the expected N-terminus site-specificity, and that these antibodies have functional immunogenicities to neutralize the toxic activity of Aβ and promote clearance of plaque deposition. The antibodies appear to draw Aβ from the CNS into peripheral circulation. Results indicate that the UBITh® AD vaccine did not evoke anti-Aβ cellular responses in a transgenic mouse model for AD. The vaccine was safe and well tolerated in adult Cynomolgus macaques during a repeat dose acute and chronic toxicity study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 16, 20 April 2007, Pages 3041–3052
نویسندگان
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