کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2408321 1103167 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunogenicity and safety of a strain-specific MenB OMV vaccine delivered to under 5-year olds in New Zealand
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Immunogenicity and safety of a strain-specific MenB OMV vaccine delivered to under 5-year olds in New Zealand
چکیده انگلیسی

To control the devastating group B meningococcal epidemic in New Zealand a strain-specific OMV vaccine (MeNZB) was extensively tested before vaccination of >1,000,000 people under 20 years. After the three-dose course 75% of 6–8-month-old infants and 16–24-month-old toddlers showed four-fold increases in bactericidal antibodies. In 6–10-week-old infants a fourth dose was needed to obtain similar results. After primary vaccination, the antibody titre decline was most pronounced among the youngest but both young infants and toddlers showed a clear booster response to a fourth dose.MeNZB was safe and well tolerated. The comprehensive post-licensure safety surveillance revealed no safety concerns.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 16, 20 April 2007, Pages 3075–3079
نویسندگان
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