کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2408321 | 1103167 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunogenicity and safety of a strain-specific MenB OMV vaccine delivered to under 5-year olds in New Zealand
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
To control the devastating group B meningococcal epidemic in New Zealand a strain-specific OMV vaccine (MeNZB) was extensively tested before vaccination of >1,000,000 people under 20 years. After the three-dose course 75% of 6–8-month-old infants and 16–24-month-old toddlers showed four-fold increases in bactericidal antibodies. In 6–10-week-old infants a fourth dose was needed to obtain similar results. After primary vaccination, the antibody titre decline was most pronounced among the youngest but both young infants and toddlers showed a clear booster response to a fourth dose.MeNZB was safe and well tolerated. The comprehensive post-licensure safety surveillance revealed no safety concerns.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 16, 20 April 2007, Pages 3075–3079
Journal: Vaccine - Volume 25, Issue 16, 20 April 2007, Pages 3075–3079
نویسندگان
P. Oster, J. O’Hallahan, I. Aaberge, S. Tilman, E. Ypma, D. Martin,