کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2408409 1103172 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification and characterization of a human monoclonal antibody that potently neutralizes a broad panel of rabies virus isolates
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Identification and characterization of a human monoclonal antibody that potently neutralizes a broad panel of rabies virus isolates
چکیده انگلیسی

Rabies is a zoonosis that results in millions of human exposures worldwide each year. Human monoclonal antibodies (HuMAbs) that neutralize rabies virus may represent one viable strategy for post-exposure prophylaxis in humans, and have many advantages over current human or equine rabies immune globulin. Transgenic mice carrying human immunoglobulin genes were used to isolate human monoclonal antibodies that neutralized rabies virus. Several HuMAbs were identified that neutralized rabies virus variants from a broad panel of isolates of public health significance. HuMAb 17C7 was the most promising antibody identified because it neutralized all rabies virus isolates tested. HuMAb 17C7 recognizes a conformational epitope on the rabies virus glycoprotein which includes antigenic site III. HuMAb 17C7 protected hamsters from a lethal dose of rabies virus in a well-established in vivo model of post-exposure prophylaxis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 15, 12 April 2007, Pages 2800–2810
نویسندگان
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