کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2408419 1103172 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective avian influenza in ovo vaccination with non-replicating human adenovirus vector
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Protective avian influenza in ovo vaccination with non-replicating human adenovirus vector
چکیده انگلیسی

Protective immunity against avian influenza virus was elicited in chickens by single-dose in ovo vaccination with a non-replicating human adenovirus vector encoding an H5N9 avian influenza virus hemagglutinin. Vaccinated chickens were protected against both H5N1 (89% hemagglutinin homology; 68% protection) and H5N2 (94% hemagglutinin homology; 100% protection) highly pathogenic avian influenza virus challenges. This vaccine can be mass-administered using available robotic in ovo injectors which provide a major advantage over current vaccination regimens. In addition, this class of adenovirus-vectored vaccines can be produced rapidly with improved safety since they do not contain any replication-competent adenoviruses. Furthermore, this mode of vaccination is compatible with epidemiological surveys of natural avian influenza virus infections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 15, 12 April 2007, Pages 2886–2891
نویسندگان
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