کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2408443 1103173 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CTA1-M2e-DD: A novel mucosal adjuvant targeted influenza vaccine
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
CTA1-M2e-DD: A novel mucosal adjuvant targeted influenza vaccine
چکیده انگلیسی

SummaryAt present few vaccine candidates exists against potentially pandemic influenza virus infections. We provide compelling evidence that a targeted fusion protein based on the CTA1-DD adjuvant and containing tandem repeats of the matrix protein 2 (M2e) ectodomain epitope, CTA1-3M2e-DD, confers strong protective immunity against a potentially lethal challenge infection with influenza virus in mice. The formulation was highly effective for mucosal immunizations and promoted high M2e-specific serum IgG and mucosal IgA antibody titers and an hitherto unknown anti-M2e CD4 T cell immunity. This novel CTA1-3M2e-DD fusion protein combines adjuvant and a conserved influenza A antigen in a promising candidate for a universal anti-influenza vaccine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 26, Issue 9, 26 February 2008, Pages 1243–1252
نویسندگان
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