کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2408464 | 1103175 | 2007 | 7 صفحه PDF | دانلود رایگان |

Gut-associated lymphoid tissue (GALT) is the primary replication site for HIV-1, resulting in a pronounced CD4+ T cell loss in this tissue during primary infection. A mucosal vaccine that generates HIV-specific CD8+ T cells in the gut could prevent the establishment of founder populations and broadcasting of virus. Here, we immunized mice orally and systemically with a chimpanzee derived adenoviral vector expressing HIV gag (AdC68gag) and measured frequencies of gag-specific interferon-gamma (IFN-γ) producing CD8+ T cells in the GALT. A single oral administration was inefficient at eliciting responses in the mesenteric lymph nodes and Peyer's Patches, while a single intramuscular administration elicited strong systemic and detectable mucosal responses. The gag-specific CD8+ T cell responses were present in both acute and memory phases following intramuscular administration.
Journal: Vaccine - Volume 25, Issue 12, 8 March 2007, Pages 2187–2193