کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2408620 1103183 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunization of macaques with formalin-inactivated human metapneumovirus induces hypersensitivity to hMPV infection
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Immunization of macaques with formalin-inactivated human metapneumovirus induces hypersensitivity to hMPV infection
چکیده انگلیسی

Human metapneumovirus (hMPV), a member of the family Paramyxoviridae, is an important cause of acute respiratory tract disease. In the 1960s, vaccination with formalin-inactivated paramyxovirus preparations – respiratory syncytial virus (RSV) and measles virus (MV) – resulted in predisposition for enhanced disease upon natural infection. We have produced a formalin-inactivated hMPV preparation (FI-hMPV), which was used to immunize young cynomolgus macaques. Six days after challenge FI-hMPV-primed monkeys had developed eosinophilic bronchitis and bronchiolitis, indicative of a hypersensitivity response. This study indicates that formalin-inactivated hMPV vaccines have the same propensity to predispose for immune-mediated disease as inactivated RSV and MV vaccines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 51, 12 December 2007, Pages 8518–8528
نویسندگان
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