کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2408809 1103191 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of the safety and immunogenicity of pneumococcal seven-valent conjugate vaccine (Prevenar®) administered in previously unvaccinated Spanish children aged 24 to 36 months
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Evaluation of the safety and immunogenicity of pneumococcal seven-valent conjugate vaccine (Prevenar®) administered in previously unvaccinated Spanish children aged 24 to 36 months
چکیده انگلیسی

This study evaluate the safety and immunogenicity of pneumococcal seven-valent conjugate vaccine (Prevenar®) in 115 children, aged 2–3 years (24–36 months), who have not been previously vaccinated with Prevenar®.Results:Safety: As for local reactions, 40% of children reported erythema, 32.2% induration and 39.1% tenderness at the injection site. Regarding systemic reactions, fever ≥38C was recorded in 7% of patients. Other commonly reported events were decreased appetite (24.3%), restlessness (20%), and fussiness (18.3%).Immunogenicity:After vaccination, more than 98% of the subjects achieved antibody levels of ≥0.15 μg/mL for all seven serotypes and more than 95% achieved antibody levels ≥0.50 μg/mL for all serotypes.Conclusions:Pneumococcal seven-valent conjugate vaccine (Prevenar®) was safe, well tolerated and highly immunogenic when administered in previously unvaccinated children aged 24–36 months.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 23, Issue 16, 14 March 2005, Pages 1917–1922
نویسندگان
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