کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2409058 1551795 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Milk IgA responses are augmented by antigen delivery to the mucosal addressin cellular adhesion molecule 1
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Milk IgA responses are augmented by antigen delivery to the mucosal addressin cellular adhesion molecule 1
چکیده انگلیسی

The mucosal addressin cellular adhesion molecule 1 (MAdCAM) is expressed on the venules of the gut associated lymphoid tissue (GALT); it is also expressed on the venules of the lobules of the mammary gland. We have previously found that MAdCAM-targeting using a rat anti-MAdCAM monoclonal Ab as both antigen and targeting moiety resulted in an enhanced local IgA gut response. We therefore surmised that such targeting may also enhance IgA responses in the mammary gland. We show that our model antigen localizes to the lobules of the mammary glands as well as the GALT, but not to the draining lymph nodes and that targeting MAdCAM results in secretory IgA responses in the milk. We provide evidence that this milk IgA Ab is of a secretory nature and is consistent with derivation from gut plasmablasts that have migrated to the mammary gland. Targeting MAdCAM may be a way for a novel vaccine strategy that affords protection to the mammary gland and the suckling neonate.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 24, Issues 27–28, 7 July 2006, Pages 5552–5558
نویسندگان
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