کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2409155 1103210 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spying the neutralizing epitopes on E2 N-terminal by candidate epitope-vaccines against classical swine fever virus
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Spying the neutralizing epitopes on E2 N-terminal by candidate epitope-vaccines against classical swine fever virus
چکیده انگلیسی

Our previous study proved that the N-terminal (aa693–711) of glycoprotein E2 contained sequential neutralizing epitopes. In this study, four candidate epitope-vaccines (EVs) were separately prepared and evaluated. Among them, epitope-vaccine EV-BC1a (BC1a: aa693–699) induced high level of epitope-specific neutralizing antibodies and exhibited similar protective capability with that induced by Chinese vaccine strain (C-strain). These results confirmed CKEDYRY (aa693–699) as a principal sequential neutralizing epitope on E2 N-terminal. Moreover, these findings also indicate that epitope-vaccine is a potent candidate strategy for marker vaccine against classical swine fever virus (CSFV).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 24, Issue 19, 8 May 2006, Pages 4029–4034
نویسندگان
, ,