کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2409216 1103212 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effectiveness of novel PGM-containing incomplete Seppic adjuvants in rabbits
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Effectiveness of novel PGM-containing incomplete Seppic adjuvants in rabbits
چکیده انگلیسی

Peptidoglycan monomer (PGM) is adjuvant active molecule in experimental mice, although its adjuvanticity is much lower in comparison to potent adjuvants. The novel adjuvant formulations were developed by incorporation of PGM into Montanide ISA 206 and Montanide ISA 720 adjuvants, with the aim to enhance its adjuvanticity by protecting it from the fast degradation and metabolic clearance. Adjuvanticity of the novel adjuvant formulations was tested in rabbits for induction of protein-specific antibodies. Both novel adjuvants ISA206PGM and ISA720PGM were significantly stronger than Montanide adjuvants themselves, and also significantly more potent than Complete Freund Adjuvant. Montanide ISA 720 was shown as much better carrier of PGM, since the novel ISA720PGM adjuvant was significantly stronger adjuvant than the ISA206PGM.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 17, 30 April 2007, Pages 3475–3481
نویسندگان
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