کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2409477 1103220 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A nematode allergen elicits protection against challenge infection under specific conditions
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
A nematode allergen elicits protection against challenge infection under specific conditions
چکیده انگلیسی
We describe tropomyosin of the filarial nematode Acanthocheilonema viteae as an allergen and study its protective potential in the natural rodent host Meriones unguiculatus (jird). Jirds immunized with recombinant E. coli-expressed A. viteae tropomyosin emusified in alum were not protected, while immunization with recombinant A. viteae tropomyosin or with protein purified from worms together with the adjuvant STP led to reduction of adult worm burdens by 30%. Vaccination with cDNA induced protection of about 30%, while application of cDNA together with aluminium phosphate increased the protection to >40%. Our data suggest that vaccination with tropomyosin under Th1 conditions, which are untypical for nematode infections, induces protection via an antibody independent effector mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 24, Issue 17, 24 April 2006, Pages 3581-3590
نویسندگان
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