کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2409543 1103222 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Convincing or confusing?: Economic evaluations of childhood pneumococcal conjugate vaccination—a review (2002–2006)
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Convincing or confusing?: Economic evaluations of childhood pneumococcal conjugate vaccination—a review (2002–2006)
چکیده انگلیسی

We review 15 economic analyses of pneumococcal conjugate vaccines, published between 2002 and 2006, in terms of methodology, assumptions, results and conclusions. We found a great diversity in assumptions (eg, vaccine efficacy parameters, incidence rates for both invasive and non-invasive disease) mainly due to local variation in data and opinions. Accordingly, the results varied greatly, from total net savings to over €100,000 per discounted QALY gained. The cost of the vaccination program (determined by price per dose and schedule (4 or 3 doses, or fewer)), and likely herd immunity impacts are highly influential though rarely explored in these published studies. If the net long-term impact (determined by a mixture of effects related to herd immunity, serotype replacement, antibiotic resistance and cross reactivity) remains beneficial and if a 3-dose schedule confers near-equivalent protection to a 4-dose schedule, the cost-effectiveness of PCV7 vaccination programs can be viewed as attractive in developed countries.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 8, 9 February 2007, Pages 1355–1367
نویسندگان
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