کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2409639 1103225 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Safety and immunogenicity of IMVAMUNE, a promising candidate as a third generation smallpox vaccine
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Safety and immunogenicity of IMVAMUNE, a promising candidate as a third generation smallpox vaccine
چکیده انگلیسی

A Phase I trial was performed to investigate the safety and immunogenicity of the third generation smallpox vaccine MVA-BN® (IMVAMUNE™), a highly attenuated clone derived from the Modified Vaccinia Virus Ankara strain 571, in naive and pre-immunized subjects. A total of 86 healthy subjects received the vaccine in five groups using different doses and routes of administration.All 38 subjects seroconverted in the groups receiving the highest dose (108 TCID50). All vaccinations were well tolerated with mainly mild or moderate pain at the injection site being the most frequent symptom. The results indicate that MVA-BN® has the potential to be developed as an efficient and safe alternative to the conventional smallpox vaccines such as Lister-Elstree or Dryvax®. Unique attributes render it a promising candidate for prophylactic mass immunization, even in subjects for whom conventional smallpox vaccines are contraindicated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 24, Issue 12, 15 March 2006, Pages 2065–2070
نویسندگان
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