کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2409924 1551797 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of acellular pertussis vaccines-induced immunity against infection due to Bordetellapertussis variant isolates in a mouse model
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Comparison of acellular pertussis vaccines-induced immunity against infection due to Bordetellapertussis variant isolates in a mouse model
چکیده انگلیسی

A significant increase in the incidence of pertussis in adolescents and adults has been observed in vaccinated populations. Concomitantly, emergence of novel pertussis toxin and pertactin types in circulating Bordetella pertussis isolates was noticed. In this study, immunity induced by acellular vaccines against infection due to isolates expressing different pertactin types and fimbriae was monitored in a mouse model. In accordance with previous studies, the effect of a bicomponent DTPa vaccine on bacterial clearance was lower when compared with tri- or pentavalent DTPa vaccines. Whatever the isolates used to infect mice, the tri- or pentavalent DTPa vaccines were both efficacious in inducing immunity that resulted in clearance of infection. These findings suggest that re-emergence of pertussis might not be related to emergence of isolates escaping vaccine protection. The present study reduces potential concerns about acellular vaccine efficacy, but frequent monitoring of protection and surveillance of the evolution of the B. pertussis population remains of particular importance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 23, Issues 46–47, 16 November 2005, Pages 5333–5341
نویسندگان
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