Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model

Respiratory syncytial virus (RSV) causes severe respiratory disease in both infants and calves. As in humans, bovine RSV (BRSV) infections are most severe in the first 6 months of life. In this study, experimental infection with BRSV was performed in calves aged 1–5, 9–16 or 32–37 weeks. Compared to younger animals, older calves showed significantly less fever and lower TNFα levels and less virus-specific IFNγ release. In addition, blood from older animals had more mononuclear cells, more B cells and stronger BRSV-specific IgA and neutralising antibody responses to infection. A strong “inflammatory” but weak humoral antiviral response in very young animals suggests that enhanced inflammation contributes to disease during RSV infection during the early postnatal period.