کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2410631 1103269 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic toxoids of Shiga toxin types 1 and 2 protect mice against homologous but not heterologous toxin challenge
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Genetic toxoids of Shiga toxin types 1 and 2 protect mice against homologous but not heterologous toxin challenge
چکیده انگلیسی
Shiga toxin type 1 (Stx1) and type 2 (Stx2) are produced by Escherichia coli O157:H7 and are responsible for the life-threatening sequela, the hemolytic uremic syndrome. Whether antisera to Stx1 or Stx2 are cross-neutralizing remains controversial, so we constructed genetic toxoids of Stx1 and Stx2 and evaluated them as vaccines. Antisera from mice immunized with a single toxoid type recognized and neutralized the homologous toxin but not the heterologous toxin. Furthermore, only mice immunized with Stx1 and Stx2 toxoids were protected against a lethal challenge of both toxins. We conclude that Stx1 and Stx2 are distinct antigens for mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 24, Issue 8, 20 February 2006, Pages 1142-1148
نویسندگان
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