Brucella spp. lumazine synthase: a novel antigen delivery system

Lumazine synthase from Brucella spp. (BLS) was evaluated as a protein carrier to improve antigen delivery of KETc1, one of the peptides of the anti-cysticercosis vaccine. KETc1 becomes antigenic, preserved its immunogenicity and its protective capacity when expressed as a recombinant chimeric protein using Brucella spp. lumazine synthase. KETc1 and BLS-KETc1 were not MHC H-2d, H-2k nor H-2b haplotype-restricted albeit KETc1 is preferentially presented in the H-2b haplotype. These findings support that BLS is a potent new delivery system for the improvement of subunit vaccines.